Medical Studies and Trials

 

Inflammation

CBD is a potent anti-inflammatory agent.

Morales, P. et al. (2017, June 28). An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487438/

 

Pre-treatment with CBD resulted in increased levels of the anti-inflammatory cytokine IL-10. CBD also reduced inflammation in acute pancreatitis of mice.

Nagarakatti, P. et al. (2009, Oct 21). Cannabinoids as novel anti-inflammatory drugs. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/

Jamontt, J. et al. (2010, May 19). The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931570/

 

Research at the University of São Paulo, Brazil, demonstrated that CBD reduced inflammation in a mouse model of acute lung injury. This effect may be mediated through the adenosine A2A receptor.

Ribeiro, A. et al. (2012, March 5). Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/22265864

 

According to research at the Sapienza University of Rome, Italy, CBD reduces inflammation in the brain caused by amyloid-beta in a rat model of Alzheimer’s disease. In the same study, CBD stimulated the formation of new nerve cells in the hippocampus, a brain region important for memory.

Esposito, G. et al. (2011, December 5). Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230631/

 

CBD binds to the GPR55 receptor, a putative cannabinoid receptor. This effect is involved in the anti-inflammatory action of the cannabinoid.

Li, K. et al. (2013, August). A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677091/

 

Pain

CBD can have an effect on pain in the varied ways it can be perceived and experienced. Evidence in this study appeared that CBD was able to influence different dimensions of response rats had to surgical incisions.

Genaro, K. et al. (2017, June 21). Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478794/

 

“CBD application has therapeutic potential for relief of arthritis pain-related behaviors and inflammation without evident side-effects.”

Hammell, D.C. et al. (2015, October 30). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851925/

 

Rest

This study provides evidence that Cannabidiol may help increase total sleep time.

Chagas, M. H. N. et al. (2013, January 23). Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23343597

 

“CBD oil can be an effective compound to reduce anxiety and insomnia secondary to PTSD.” This case report conducted with a 10-year old girl suffering from PTSD provides insight to show how CBD can help individuals living with the hardship of PTSD related ailments.

Shannon, S. (2016, October 12). Effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/

 

Stress and Anxiety

In an experiment with 48 healthy participants who underwent a fear-conditioning test CBD enhanced consolidation of subsequent extinction learning and thus may be helpful in anxiety disorders.

Das, R. K. et al. (2013, January 10). Cannabidiol enhances consolidation of explicit fear extinction in humans. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/23307069

 

CBD inhibits the uptake and hydrolysis of the endocannabinoid anandamide, thus increasing its concentration.  Anandamide is a neurotransmitter produced in the brain that binds to the THC receptors. It’s been called the “bliss molecule,” aptly named after ananda, the Sanskrit word for “joy, bliss, or happiness.”

Bisogno, T. et al. (2009, January 29). Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573017/

 

Pre-treatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in the speech performance of patients with social anxiety disorder, and significantly decreased alert in their anticipatory speech.

Bergamaschi, M. M. et al. (2011, February 9). Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079847/

 

Other

In research at the Cajal Institute in Madrid, Spain, CBD was able to modulate the function of microglia, immune cells in the brain, in a mouse model of Alzheimer‘s‘ disease. Scientists noted that given that CBD lacks psychoactivity it may represent a novel therapeutic approach for this neurologic disease.“

Martin-Moreno, A. M. et al. (June, 2011). Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102548/

 

The proliferation of human skin cells was influenced by the cannabinoids CBD and cannabigerol (CBG). Authors concluded that this suggests “(especially for CBD) a possible exploitation as lead compounds to be used in the development of novel therapeutics for skin diseases.”

Pucci, M. et al. (2013, September 17). Epigenetic control of skin differentiation genes by phytocannabinoids. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791996/

 

CBD acts as an antagonist at the central CB1 receptor and was able to inhibit several CB1 mediated THC effects.

Zuardi, AW. et al. (1982). Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/6285406

 

C8 MCT (Caprylic) Oil

“Caprylic acid is superior to & less expensive than Diflucan, & has potential application for anti-cancer, anti-aging, anti-Alzheimer’s disease, anti-Autism, anti-infection, & general circulatory improvement.”

Omura, Y. et al. (2011). Caprylic acid in the effective treatment of intractable medical problems of frequent urination, incontinence, chronic upper respiratory infection, root canalled tooth infection, ALS, etc., caused by asbestos & mixed infections of Candida albicans, Helicobacter pylori & cytomegalovirus with or without other microorganisms & mercury. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21830350

 

Caprylic’s aid in absorption rates of over 2 1/2 times its long-chain counterparts.

Jandacek, RJ. et al. (1987, May 1). The rapid hydrolysis and efficient absorption of triglycerides with octanoic acid in the 1 and 3 positions and long-chain fatty acid in the 2 position. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/3578095

 

This study provides evidence of Caprylic efficacy in treating fungal infections.

Jadhav, A. et al. (2017, September 18). The Dietary Food Components Capric Acid and Caprylic Acid Inhibit Virulence Factors in Candida albicans Through Multitargeting. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28922057

 

This study provides evidence of Caprylic combinations ability to help eradicate microbial organisms.

Rosenblatt, J. et al. (2017, October 18). Caprylic and Polygalacturonic Acid Combinations for Eradication of Microbial Organisms Embedded in Biofilm. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29093703

 

Antibacterial effects of Caprylic combinations for bacterial pathogens in bovines.

Nair, MK. et al. (2005, October). Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16162522

 

This study provides evidence of Caprylic combinations’ ability to reduce cholesterol concentrations.

Wilson, TA. et al. (2006, March). Structured triglycerides containing caprylic (8:0) and oleic (18:1) fatty acids reduce blood cholesterol concentrations and aortic cholesterol accumulation in hamsters. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16580874